Allergy Medicine

Allergen complexed with cationic lipid prevents allergic responses

Published in Vaccine Weekly, August 17th, 2005

Vaccination with the recombinant allergen ProDer p 1 complexed with the cationic lipid DiC14-amidine prevents allergic responses to house dust mites.

"The present study evaluated the prophylactic potential of ProDer p 1, the recombinant precursor form of the major mite allergen Der p 1, combined with the cationic lipid diC14-amidine in a murine model of house dust mite allergy. Naive mice vaccinated with the amidine/allergen complex developed a Th1-biased immune response characterized by the absence of specific IgE, the production of specific IgG2a, and the presence of IFN-gamma in splenocyte cultures," scientists in Belgium report.

"In contrast,...

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Source: Vaccine Weekly (2005-08-17)

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