Published in Vaccine Weekly, August 24th, 2005
Study 1: Immunization with a multiclade envelope HIV vaccine candidate expands the extent of virus neutralization.
"Although the V3 loop of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) effectively elicits potent neutralizing antibody responses, the specificity of the antibody response is often restricted to T cell line adapted (TCLA) strains and a small subset of primary isolates, limiting its utility for an AIDS vaccine. In this study, we have compared Env immunogens with substituted V3 regions to combinations of strains...
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Source: Vaccine Weekly (2005-08-24)
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