DNA Vaccine

Role of particle-mediated DNA vaccines in biodefense reviewed

Published in Vaccine Weekly, August 24th, 2005

Researchers review the role of particle-mediated DNA vaccines in biodefense preparedness in a recent issue of Advanced Drug Delivery Reviews.

According to a study from the United States, "Particle-mediated epidermal delivery (PMED) of DNA vaccines is based on the acceleration of DNA-coated gold directly into the cytoplasm and nuclei of living cells of the epidermis, facilitating DNA delivery and gene expression. Professional antigen-presenting cells and keratinocytes in the skin are both targeted, resulting in antigen presentation via direct transfection and cross-priming mechanisms."

"Only a small number of cells need to be transfected to...

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Source: Vaccine Weekly (2005-08-24)

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