Colon Cancer Vaccine

Oral vaccine induces immune responses against carcinoembryonic antigen

Published in Vaccine Weekly, September 7th, 2005

An oral vaccine induced mucosal and systemic immune responses against human carcinoembryonic antigen.

"Carcinoembryonic antigen (CEA) is a tumor-associated antigen targeted for the development of colorectal tumor vaccines. In this study, we developed papillomavirus pseudoviruses encoding the truncated CEA without NH₂ -terminal signal peptide (PV-CEA) as an oral vaccine to induce CEA-specific CTL responses. In CEA transgenic (CEA-Tg) mice orally immunized with PV-CEA, the immunologic tolerance to CEA as a 'self-antigen' was overcome and both mucosal and systemic CEA-specific cytolytic activities were detected by in vitro ⁵¹Cr release assays,"...

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Source: Vaccine Weekly (2005-09-07)

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