Vaccine Vector
Interference with IL-1-signaling reduces toxicity of adenovirus vectors
Published in Vaccine Weekly, September 7th, 2005
According to a study from the United States, "The safety of gene therapy vectors is a major concern when novel viral or nonviral therapeutics are proposed for applications in humans. Adenovirus (Ad) vectors have been extensively used as efficient gene delivery vehicles in vitro over the last 2 decades. However, upon i.v. application, they elicit robust innate and inflammatory responses that may be fatal for the host. To date, the primary cytokines and chemokines involved in the initiation of these host responses remain illusive."
"In...
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Source: Vaccine Weekly (2005-09-07)
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