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Vaccine Weekly

Susan Hasty, Publisher
Table of Contents . . . September 14th, 2005
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Vaccine Weekly | Other Publications

Autism Risk Factors - MMR vaccine withdrawal has not affected incidence of autism

HIV/AIDS Vaccine - HIV-1 canarypox vaccine benefits chronically HIV-infected patients

Pertussis Vaccine - Bordetella pertussis strain variation in Finland examined

Protein Production - Recombinant protein produced using HeLaS3-vaccinia virus system

Staphylococcal Vaccine - Peptide mimics TRAP antigen epitope of Staphylococcus aureus

Allergy & Immunology - New allergen exposure may act as adjuvant to initial allergen

Allergy & Immunology - Pharmaceutical company launches epinephrine auto-injector for anaphylaxis

Allergy Medicine - New findings in the area of allergy medicine described

Anthrax Vaccine - Influenza proteins containing B. anthracis antigen characterized

Anthrax Vaccines - Reports add new data to anthrax vaccines research

Antiproliferative Activity - Hopane and oleanane glycosides exhibited antiproliferative activity

Cancer Vaccines - Recent findings in cancer vaccines provide new insights

Apoptosis - Data advance knowledge in apoptosis research

Apoptosis - Panduratin A induced apoptosis

Apoptosis - Pristimerin induced caspase-dependent apoptosis in MDA-MB-231 cells

Arthritis Therapy - IL-1BETA peptides designed by molecular modeling improve arthritis

Arthritis Vaccine - Gene transfer to human joints accomplished

Botulism Vaccine - Botulinum neurotoxin heavy chain fragments formulated for vaccine development

DNA Vaccines - Studies describe new findings in DNA vaccines research

Breast Cancer - New treatment for breast cancer and choroidal metastasis described

Breast Cancer - Phase II and tumor pharmacodynamic study of gefitinib conducted

Breast Cancer - Preliminary results from breast cancer vaccine trial reported

Breast Cancer - Temsirolimus, a novel inhibitor of MTOR, studied

Business & Finance - RNAi-focused company reports Q2 results

Business Update - Company signs contract for prototype module for DNA manufacturing

HIV/AIDS Vaccines - Reports advance knowledge in HIV/AIDS vaccines research

Campylobacter Vaccine - Campylobacter jejuni vaccine protects ferrets against infection

Cancer Research - Company announces publication that pinpoints TAP defect in metastatic carcinomas

Cancer Therapy - Cellular distribution of dinuclear platinum anticancer drugs detected

Cancer Therapy - New insight may improve the potential of cancer vaccines

Cancer Vaccine - Melanoma vaccine induces spontaneous CD4+ T-cell responses

Cancer Vaccines - Recent findings in cancer vaccines described

HIV/AIDS Vaccines - Researchers' data advance HIV/AIDS vaccines research

Chickenpox Outbreak - Varicella outbreak work center for handicapped adults reported

Collaborations - Agreement signed with University of Washington for anticancer compound

Collaborations - Pharma company exercises rights to Centocor's CNTO 148

Colon Cancer - 17-Allylamino-17-demethoxygeldanamycin overcame TRAIL resistance in colon cancer

Cystic Fibrosis Therapy - Plasmid DNA vectors detected following gene transfer to murine airways

Malaria Vaccines - Researchers publish new studies and findings in the area of malaria vaccines

DNA Vaccine - Cationic PLA nanoparticles for DNA delivery compared

DNA Vaccine - In utero DNA immunization examined

DNA Vaccines - Findings describe new data in DNA vaccines research

Dendritic Cell Vaccine - HLA-DO transduced in dendritic cells modulates MHC antigen processing

Dendritic Cell Vaccine - Reporter gene expression in dendritic cells examined

Malaria Vaccines - Researchers report details of new studies and findings in the area of malaria vaccines

Dengue Fever Vaccine - Dengue type-2 vaccine candidates evaluated in rhesus macaque model

Drug Development - Biopharma firm responds to RFI on development of HIV/AIDS vaccines

Echinococcosis Vaccine - Economic effects of echinococcosis in endemic region of China discussed

Evolutionary Biology - Species evolve to the brink of evolution

Finance - ATryn developer reports Q2 net loss of $7.1 million

Finance - Molecular biotechnology company posts narrowed quarterly loss

Melanoma Vaccines - Reports advance knowledge in melanoma vaccines research

Finance - Molecular medicine-focused company reports results for first half of 2005

Finance - RiVax maker reports improved net loss in Q2

Forphenicinol - Forphenicinol enhanced antitumor effects of cyclophosphamide in a model of SCC

Gastric Cancer - Oxaliplatin and SN-38 interacted synergistically in human gastric cancer cells

Glioblastoma Multiforme - Efficacy of temsirolimus in recurrent glioblastoma multiforme evaluated

HIV/AIDS Diagnostics - Rapid HIV and HIV/hepatitis C tests being registered internationally

Tuberculosis Vaccines - Researchers detail new studies and findings in the area of tuberculosis vaccines

HIV/AIDS Vaccine - Antigen-presenting cells and HIV antigen do not affect vaccine efficacy

HIV/AIDS Vaccine - Host environment drives HIV-1 fitness

HIV/AIDS Vaccine - Impact of HIV-1 genetics on commercial viral load assays examined

HIV/AIDS Vaccine - Measles vector primes neutralizing antibodies against HIV epitopes

HIV/AIDS Vaccine - RNA targeted against LTR region inhibits HIV-1 replication

HIV/AIDS Vaccines - Data advance knowledge in HIV/AIDS vaccines research

Tuberculosis Vaccines - Researchers publish new studies and findings in the area of tuberculosis vaccines

Haemophilus Vaccines - Reports describe recent advances in haemophilus vaccines research

Helicobacter Vaccine - Mast cells mediate vaccine-induced Helicobacter clearance

Helicobacter Vaccine - Oral vaccine shows promise for eradication of Helicobacter pylori

Hepatitis A Therapy - FDA approves expanded age indication for Vaqta hepatitis A vaccine

Vaccines Adjuvant - Studies add new findings to vaccines adjuvant body of knowledge

Hepatitis B Virus - Resources and noncompliance remain barriers to HBV prevention

Hepatitis C Virus - Hepatitis A vaccine not widely used for hepatitis C patients

Hepatitis C Virus Vaccine - Recombinant adenovirus/monoclonal antibody combination useful in HCV strategies

Herpes Vaccine - Plasmid-encoded IL-15 sustains anti-herpes virus immunity

Human Papillomavirus - Multiplexed luminex assay to quantify HPV antibodies optimized

Immunology - Immunization of mice with liquor from zooid of Antheraea pernyi studied

Vaccines Vector - Researchers' findings advance vaccines vector research

Immunotherapy - Vaccine pioneer Dr. Stanley A. Plotkin named to board of directors

Influenza - Relenza being stockpiled in Germany

Influenza A Virus - Isolation and characterization of H3N2 influenza A virus from turkeys

Influenza Vaccine - Effective nasal influenza vaccine delivery using chitosan

Influenza Vaccine - Neuraminidase-expressing DNAs protect against influenza virus infection

Influenza Vaccine - Whole influenza virus vaccine more immunogenic than split vaccine

Leukemia - 5-Aza-2'-deoxycytidine combined with valproic acid to treat leukemia

Leukemia - Immune system finding paves way for vaccine use in leukemia, lymphoma

Leukemia Vaccine - Leukemia-derived dendritic cells generated from myelodysplasia patients

Lewy Body Disease - Alpha-synuclein shows promise against Lewy body disease

Liposomal Delivery - Sphingomyelin/cholesterol liposome formulation of VRL showed antitumor activity

Lung Cancer - 7Beta-hydroxycholesterol showed cytotoxic effect on human lung cancer cells

Lymphoma - Single-agent temsirolimus evaluated for mantle cell lymphoma

MEK Inhibitor - Phase I and pharmacodynamic study of oral MEK inhibitor CI-1040 conducted

Malaria Vaccine - Induction of IgG to P. falciparum surface antigens investigated

Malaria Vaccine - Method for malaria vaccine development uses full-length cDNA libraries

Malaria Vaccine - Quantitative real-time PCR method for malaria diagnosis developed

Malaria Vaccines - New data illuminates research in malaria vaccines

Measles Vaccine - Enhancing of measles virus infection by magnetofection

Measles Vaccine - Immune responses induced by measles DNA vaccines characterized

Melanoma Vaccines - Findings advance knowledge in melanoma vaccines research

Meningitis Vaccines - Studies add new findings to meningitis vaccines body of knowledge

Meningococcal Vaccine - Measurement of Norwegian MenBvac vaccine activity standardized

Neolignans - Neolignans from Saururus chinensis showed cytotoxic effects in cancer cells

Nippostrongylus Vaccine - Immune response to Nippostrongylus brasiliensis described

Ovarian Cancer - CA-125 test has higher levels of sensitivity and specificity when run with DR-70

Pancreatic Adenocarcinoma - Histone deacetylase inhibitors induced caspase-independent apoptosis

Pathway Inhibitors - LY293111, a novel diaryl ether carboxylic acid derivative studied

Pediatric Vaccine - Influenza vaccines needed for children younger than 5 years

Pediatric Vaccine - Mother's education level increases likelihood of child immunization

Personnel - Antigen Express hires staff to accelerate pandemic influenza vaccine development

Personnel - Antiviral therapeutic products company appoints executive vice president and CFO

Pertussis Vaccine - Bordetella pertussis populations in Europe analyzed

Pertussis Vaccine - Economic factors of pertussis booster in adolescents reviewed

Pertussis Vaccine - Overview of pertussis presented

Pertussis Vaccines - New findings in the area of pertussis vaccines described

Phosphatase Inhibitors - Design, synthesis, and biological evaluation of novel naphthoquinone derivatives

Plague Vaccine - Yersinia pestis outer membrane secretion protein characterized

Pneumococcal Vaccine - Antibodies to pneumococcal protein protect against Streptococcus

Pneumococcal Vaccine - Pneumococcal anticapsular IgG linked to nasopharyngeal pneumococcus

Poxvirus Vaccine - Inhibition of Abl tyrosine kinases disables poxvirus pathogenesis

Poxvirus Vaccine - Lessons from IL-4-expressing poxviruses outlined

Product Licensing - Vaccine portfolio licensed from Baxter Healthcare

Prostate Cancer - Endothelin-1 inhibited apoptosis in prostate cancer

Prostate Cancer Vaccines - Recent findings illuminate research in prostate cancer vaccines

Protein Production - Artificial oil bodies used for expression of nattokinase in E. coli

Rabies Risk Factors - Risk of rabies entering Great Britain from North America assessed

Rabies Vaccines - Reports describe recent advances in rabies vaccines research

Respiratory Syncytial Virus - IL-4 expression by RSV linked to nonfunctional CTL response

Respiratory Syncytial Virus - Recombinant immunogens enhance cellular and antibody immune responses

Rubella Vaccine - High rubella seronegativity found in daycare educators in Canada

SARS - Study shows how fractions of flu medicine inhibit protease encoded by SARS virus

SARS Vaccine - Monoclonal antibodies to SARS-associated coronavirus identified

Saponins - Cytotoxic effect of saponins characterized

Schistosomiasis Vaccine - Vaccine candidate from Schistosoma japonicum characterized

Schistosomiasis Vaccine - Vaccine induces partial protection against experimental schistosomiasis

Smallpox Vaccines - Researchers provide details of new studies and findings in the area of smallpox vaccines

Smallpox Vaccines - U.S. issues RFP for purchase of 20 million doses of MVA-based smallpox vaccine

Syphilis Diagnosis - Skin assay used to assess immunity against Treponema epitope

Tick-Borne Disease - Ixodes scapularis cDNAs protective against ticks characterized

Toxoplasmosis Vaccine - Efficacy of multi-antigenic vaccines against toxoplasmosis examined

Transplantation Medicine - Hepatitis B core antibody positive donors safe for lung transplantation

Tuberculosis Diagnosis - Mycobacterium tuberculosis protein p27 characterized

Tuberculosis Epidemiology - Latent tuberculosis infection in medical students in Brazil examined

Tuberculosis Prevention - Boosting the BCG vaccine could beat tuberculosis

Tuberculosis Risk Factors - TB infection in child contacts of tuberculosis patients studied

Tuberculosis Vaccine - Antigens with potential in tuberculosis vaccines identified by new technologies

Tuberculosis Vaccine - New vaccines against tuberculosis under development

Tuberculosis Vaccine - Routes of immunization for mucosal vaccine against TB compared

Tuberculosis Vaccine Development - 'Go no-go' decisions in TB vaccine development balances risk/time/resources

Tuberculosis Vaccines - Recent studies add new data to tuberculosis vaccines research

Tularemia Vaccines - Researchers describe findings in tularemia vaccines studies

Typhoid Fever - Outbreak of typhoid fever in vaccinated Armed Forces members reported

Typhoid Vaccine - Oral typhoid vaccine well tolerated and highly immunogenic

Vaccine Development - Influenza vaccine under development could offer permanent protection

Vaccine Development - Polio vaccine produced on MRC-5 cells or monkey kidney cells compared

Vaccine Development - Promoters for antigen expression in Salmonella enterica examined

Vaccine Development - U.S. government issues RFP for MVA smallpox vaccine

Vaccine Efficacy - Heterogeneous alterations in alloimmunity associated with immunization

Vaccine Efficacy - Immunization data quality audit reviewed

Vaccine Efficacy - Inflammatory response to vaccination is altered in elderly

Vaccine Safety - Mercury in monkeys exposed to methylmercury or thimerosal determined

Vaccine Vector - Purification of plasmid DNA vectors described

Vaccine Vectors - Sindbis virus-based vectors targeted to Fc receptor-positive cell types

Vaccines Adjuvant - Data advance knowledge in vaccines adjuvant research

Vaccines Vector - Research add new data to vaccines vector body of knowledge

Viral Vectors - New research in the area of viral vectors detailed

Virology - Polyomavirus agnoprotein dissociates heterochromatin protein

Virology - Researchers publish new studies and findings in the area of virology

Virology Vaccine - QPCR used to assign infectious potencies to adenovirus-based vaccines

Virology Vaccine - Semliki Forest virus and Kunjin virus RNA replicons investigated

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