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Apoptosis
Pristimerin induced caspase-dependent apoptosis in MDA-MB-231 cells
September 14th, 2005
Pristimerin induced caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria. According to recent research from Taiwan, "Pristimerin, a naturally occurring triterpenoid, has been shown to cause cytotoxicity in several cancer cell lines. However, the mechanism for the cytotoxic effect of pristimerin was never explored." "In the present study, human breast cancer MDA-MB-231 cells treated with pristimerin (1 and 3 mc mol/L) showed rapid induction of apoptosis, as indicated by caspase activation, DNA fragmentation, and morphologic changes. Pretreatment of a pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone...
Source: Vaccine Weekly (2005-09-14)
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