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Arthritis Therapy
IL-1BETA peptides designed by molecular modeling improve arthritis
September 14th, 2005
Active immunization against murine IL-1BETA peptides designed by molecular modeling improved collagen-induced arthritis. "Interleukin-1beta (IL-1beta) is a crucial cytokine in inflammation processes and has been implicated in the pathogenesis of several chronic inflammatory diseases. Strategies designed to blocking IL-1beta by passive administration of inhibitors (mAbs, IL-1 receptor antagonist) have previously demonstrated efficacy in rheumatoid arthritis (RA). Using molecular modeling, we have defined three murine IL-1beta peptide regions characterized by their close proximity to the receptor," scientists in France report. "Synthetic peptides...
Source: Vaccine Weekly (2005-09-14)
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