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Arthritis Vaccine
Gene transfer to human joints accomplished
September 14th, 2005
Researchers have accomplished the gene transfer to human joints. "This article describes the clinical application of gene therapy to a nonlethal disease, rheumatoid arthritis (RA). Intra-articular transfer of IL-1 receptor antagonist (IL-1Ra) cDNA reduces disease in animal models of RA. Whether this procedure is safe and feasible in humans was addressed in a phase I clinical study involving nine postmenopausal women with advanced RA who required unilateral sialastic implant arthroplasty of the 2nd-5th metacarpophalangeal (MCP) joints," scientists in the United States report. "Cultures of autologous synovial fibroblasts were established and divided...
Source: Vaccine Weekly (2005-09-14)
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