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Cancer Therapy
Cellular distribution of dinuclear platinum anticancer drugs detected
September 14th, 2005
The cellular distribution of dinuclear platinum anticancer drugs were detected by fluorescence microscopy. "The dinuclear platinum complexes with aliphatic diamines [{cis-Pt(NH(3))(2)Cl}(2)(mu-H(2)N(CH(2))(6)NH(2))](NO(3))(2) (1,1/c,c) and [{trans-Pt(NH(3))(2)Cl}(2)(mu-H(2)N(CH(2))(4)NH(2))](NO(3))(2) (1,1/t,t), which are known to be highly active in vitro against several cancer cell lines, have been modified with a fluorogenic reporter (carboxyfluorescein diacetate, CFDA) and a hapten (dinitrophenyl, DNP)," researchers in the Netherlands reported. "These labeled complexes have been designed for fluorescence microscopy investigation of cellular...
Source: Vaccine Weekly (2005-09-14)
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