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Cancer Vaccines
Recent findings in cancer vaccines described
September 14th, 2005
Cancer vaccines research advances have been reported from the United Kingdom, United States and Australia. Study 1: Investigators have conducted a phase I study of TNF-alpha AutoVaccIne in patients with metastatic cancer. "We evaluated the safety and immunogenicity of a novel vaccine directed against autologous TNF-alpha in a phase I fixed-dose escalation trial. The vaccine consisted of two recombinant TNF-alpha proteins, with specific peptides replaced by foreign immunodominant T cell epitopes from tetanus toxoid. The main objectives were to establish a safe dose and evaluate the vaccines ability to raise neutralizing TNF-alpha antibodies. Secondary...
Source: Vaccine Weekly (2005-09-14)
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