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Cystic Fibrosis Therapy
Plasmid DNA vectors detected following gene transfer to murine airways
September 14th, 2005
Scientists have detected plasmid DNA vectors following gene transfer to the murine airways. According to recent research from England AND THE United States, "Non-viral gene therapy is being considered as a treatment for cystic fibrosis. In clinical studies and in studies using the mouse airways as a model, current formulations result in only transient transgene expression. A number of reasons for this have been proposed including the loss of plasmid DNA from cells. The aim of these studies was to investigate why transgene expression from non-viral vectors is transient in the mouse lung." "Plasmid DNA encoding the luciferase reporter gene was...
Source: Vaccine Weekly (2005-09-14)
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