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DNA Vaccine
Cationic PLA nanoparticles for DNA delivery compared
September 14th, 2005
Researchers compare three surface polycations for DNA binding, protection, and transfection properties of cationic PLA nanoparticles for DNA delivery in a recent issue of Colloids and Surfaces B - Biointerfaces. "Biodegradable cationic nanoparticles (cNP) made of poly(lactide) (PLA) have been shown to be promising carrier systems for in vivo DNA delivery and immunization. In previous work, we have described a versatile approach for the elaboration of cationic PLA cNP based on the use of pre-formed particles and subsequent adsorption of a model polycation, the poly(ethylenimine) (PEI). Here, we evaluated two more polycations, chitosan and...
Source: Vaccine Weekly (2005-09-14)
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