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Dendritic Cell Vaccine
HLA-DO transduced in dendritic cells modulates MHC antigen processing
September 14th, 2005
HLA-DO transduced in human monocyte-derived dendritic cells modulates MHC class II antigen processing. "Through the regulation of human leukocyte antigen (HLA)-DM (DM) in B cells, HLA-DO (DO) modulates positively or negatively the presentation of specific peptides. Transduction of DO into human blood monocyte-derived dendritic cells (MoDC) has been proposed as a mean of modifying the peptide repertoire of major histocompatibility complex class II molecules," researchers in Canada report. "However, maturation of DC induced by inflammatory stimuli or possibly the adenoviral vector itself triggers acidification of vesicles and shuts down transcription...
Source: Vaccine Weekly (2005-09-14)
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