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Dendritic Cell Vaccine
Reporter gene expression in dendritic cells examined
September 14th, 2005
Scientists describe reporter gene expression in dendritic cells after gene gun administration of plasmid DNA in a recent issue of Vaccine. "Dendritic cells (DC) play an integral role in plasmid DNA vaccination. However, the interaction between plasmid DNA and DC in vivo is incompletely understood. In this report, we utilize the sheep pseudo-afferent cannulation model to examine the interaction between plasmid DNA encoding enhanced green fluorescent protein (pEGFP) and afferent lymph DC (ALDC) in the United Kingdom report. "The results show that peaks of fluorescent ALDC tended to appear around days 1-4 and 9-13, then erratically thereafter for...
Source: Vaccine Weekly (2005-09-14)
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