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Staphylococcal Vaccine
Peptide mimics TRAP antigen epitope of Staphylococcus aureus
September 14th, 2005
A novel peptide screened by phage display can mimic the TRAP antigen epitope against Staphylococcus aureus infections. According to a study from China, "Staphylococcus aureus is a major human pathogen. Pathogenic effects are largely due to production of bacterial toxins, whose synthesis is controlled by an mRNA molecule termed RNAIII. The S. aureus protein called RAP (RNAIII-activating protein) is secreted and activates RNAIII production by inducing the phosphorylation of its target protein TRAP (target of RAP)." "Antibodies to TRAP have been shown to suppress exotoxin production by S. aureus in vitro, suggesting that TRAP...
Source: Vaccine Weekly (2005-09-14)
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