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HIV/AIDS Vaccine
Antigen-presenting cells and HIV antigen do not affect vaccine efficacy
September 14th, 2005
Systemic mobilization of antigen-presenting cells, with a chimeric FLT-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens, is insufficient to modulate immune responses or vaccine efficacy. According to a study from the Netherlands, United States, and Germany, "In order to improve the efficacy of current vaccine candidates against HIV/AIDS, we sought to strengthen the induction of immune responses via simultaneous in vivo mobilization of dendritic cells using a chimeric Flt-3 and G-CSF receptor agonists (ProGP). We investigated ProGP treatment in combination with two DNA immunizations encoding HIV-Env89.6, SIV-Gag proteins to...
Source: Vaccine Weekly (2005-09-14)
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