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HIV/AIDS Vaccine
Measles vector primes neutralizing antibodies against HIV epitopes
September 14th, 2005
A recombinant live attenuated measles vaccine vector primes effective HLA-A0201-restricted cytotoxic t lymphocytes and broadly neutralizing antibodies against HIV-1 conserved epitopes. According to a study from France, "Live attenuated measles vaccine (MV) could provide a safe and efficient pediatric vaccination vector to immunize children simultaneously against measles and human immunodeficiency virus type 1 (HIV-1). To evaluate the capacity of a vector derived from the certified Schwarz measles vaccine (MVSchw) to prime effective cytotoxic T cells (CTL) and broad neutralizing antibodies against HIV-1 conserved epitopes, we generated recombinant MVSchw viruses...
Source: Vaccine Weekly (2005-09-14)
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