Influenza Vaccine

Whole influenza virus vaccine more immunogenic than split vaccine

Published in Vaccine Weekly, September 14th, 2005

Whole influenza virus vaccine is more immunogenic than split influenza virus vaccine and induces primarily an IGG2A response in BALB/c mice.

According to a study from Norway, "The aim of this study was to compare the kinetics and the magnitude of the humoral immune response to two different influenza vaccine formulations, whole and split virus vaccines. BALB/c mice were immunized intramuscularly with one or two doses (3 weeks apart) of 7.5, 15 or 30 mcg of hemagglutinin of monovalent A/Panama/2007/99 (H3N2) split or whole virus vaccine."

"The two vaccine formulations induced similar kinetics of the antibody-secreting cells response; however,...

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Source: Vaccine Weekly (2005-09-14)

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