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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . September 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Cancer Vaccine Development - Dendritic cell vaccine accelerates CD8+ memory and prime-boost response

Cancer Vaccine Development - Human carcinoembryonic antigen-based cancer vaccines reviewed

Cancer Vaccine Development - Mimotope peptide-based anti-cancer vaccine developed

HIV/AIDS Vaccine - HIV type 1 Tat protein induces neutralizing antibodies

Helicobacter Vaccine Development - Vaccine development for gastric cancer and Helicobacter reviewed

Addiction Medicine - Vaccine pharmacotherapy for treatment of cocaine dependence determined

Allergy & Immunology - Allergen-specific IgG linked to reduced nasal allergen sensitivity

Anthrax - Researchers report details of new studies and findings in the area of anthrax

Anthrax Vaccines - Recent findings illuminate research in anthrax vaccines

Bioterrorism - BioThrax maker expands global marketing reach

Cancer Vaccines - Researchers report details of new studies and findings in the area of cancer vaccines

Bioterrorism - Dutch biotech, U.S. Navy to test AdVac-based vaccine against anthrax, plague

Business Update - Biotech company completes corporate name change to Panacos Pharmaceuticals, Inc.

Cancer Inhibitors - Histone deacetylase inhibitors affected Ewing family tumors

Cancer Therapy - Camptothecin derivatives synthesized

Cancer Vaccine Development - Folate receptor-targeted immunotherapy reviewed

HIV/AIDS Vaccines - Research add new data to HIV/AIDS vaccines body of knowledge

Cancer Vaccine Development - Reduced anti-tumor effect of DC vaccine linked to increase in NKT cells

Cancer Vaccines - Research in cancer vaccines provides new insights

Chemotherapy - Mylotarg administered after start of chemotherapy produced high remission rate

Cholera Vaccine - Virulence factors and vaccine protection in cholera examined

Cholera Vaccine Development - Immune response kinetics after immunization with cholera toxin reported

HIV/AIDS Vaccines - Researchers' work adds to HIV/AIDS vaccines body of knowledge

Chronic Myelogenous Leukemia - Protein kinase inhibitors put under high throughput screening

Constipation - Positive results from methylnaltrexone phase 3 clinical trial reported

Cytomegalovirus - Two binding sites in enhancer of CMV play role in viral replication

DNA Vaccine - Cationic microparticles developed as carriers systems for DNA vaccines

DNA Vaccine - Gene delivery improvement mediated by dendrimer/alpha-cyclodextrin conjugates

Diabetes Therapy - Polymeric gene carrier developed for insulin-secreting cells

HIV/AIDS Vaccines - Studies add new findings to HIV/AIDS vaccines body of knowledge

Diabetes Therapy - Safety and efficacy of insulin gene transfer to diabetic rats reported

Disease Associations - Researchers publish new studies and findings in the area of disease associations

Drug Development - West Nile vaccine shows 100% protection in durability study

Ebola Fever - Effects of Ebola virus glycoproteins on endothelial cell activation outlined

Epidemiology - Similarity shown between two bacterial meningitis strains

Etoposide - Irinotecan, etoposide used in previously untreated, extensive SCLC

HIV/AIDS Vaccines - Studies advance knowledge in HIV/AIDS vaccines research

Finance - Biopharma company reports revenue of $71.3 million

Finance - U.S. NIH awards $1.2M for study of skin's barrier function related to vaccine

HIV/AIDS Research - Milestone payment received for Reverset study 203

HIV/AIDS Research - Phase 2a clinical study of PA-457 complete, preliminary analysis reported

HIV/AIDS Vaccine Development - CD8+ depletion reduced virus levels of virus in SIV-vaccinated macaques

HIV/AIDS Vaccine Development - DNA prime and adenovirus boost enhance immunity to HIV immunogens

Malaria Vaccines - Researchers provide details of new studies and findings in the area of malaria vaccines

HIV/AIDS Vaccine Development - DNA vaccines expressing SIV antigens decrease viremia upon challenge

HIV/AIDS Vaccine Development - Determinants of HIV resistance to membrane-anchored peptides reported

HIV/AIDS Vaccine Development - Factors affecting retention in HIV vaccine clinical trials examined

HIV/AIDS Vaccine Development - Glycosylation affects efficacy of an Env-based vaccine against SIV

HIV/AIDS Vaccine Development - HIV vaccine reduces CD8+ expansion but improves virus control

HIV/AIDS Vaccine Development - Priming-boosting regimen enhance plasmid DNA microparticle HIV vaccines

Tuberculosis Vaccines - New data illuminates research in tuberculosis vaccines

HIV/AIDS Vaccine Development - Properties of peptide mimotopes of HIV carbohydrate antigens outlined

HIV/AIDS Vaccine Development - Replicating adenovirus-HIV vaccines elicit high cellular immunity

HIV/AIDS Vaccine Development - Treated virions elicit high-titer neutralizing antibodies

HIV/AIDS Vaccines - Recent studies add new data to HIV/AIDS vaccines research

Tuberculosis Vaccines - Recent findings illuminate research in tuberculosis vaccines

Helicobacter Vaccine Development -  H. pylori oral vaccine elicits systemic and mucosal immunity

Herpes Vaccine Development - Parents' willingness to vaccinate children against herpes examined

Human Papillomavirus Vaccines - Recent findings illuminate research in human papillomavirus vaccines

Immunology - CD4-CD8- T cells control intracellular bacterial infections

Tuberculosis Vaccines - Reports add new data to tuberculosis vaccines research

Immunotoxicity - Biomarkers assess potential developmental immunotoxicity in children

Influenza - CMS proposal would require nursing homes to vaccinate residents against the flu

Influenza Vaccine Development - Patient care team involvement increases influenza vaccination rates

Influenza Vaccine Development - Perforin and Fas pathways affect influenza CD8+ escape variants

Influenza Vaccines - New research in the area of influenza vaccines detailed

Influenza Virus - Attenuated mutant influenza strain developed for vaccine use

Tuberculosis Vaccines - Researchers report details of new studies and findings in the area of tuberculosis vaccines

Inhibitors - Flavonoid glycosides inhibited oral cancer cell proliferation

Leucovorin - Intravenous 5-FU compared to oral UFT both modulated by leucovorin

Lung Cancer - Asian ethnicity and adenocarcinoma histology predicted response to gefitinib

Lung Cancer - Reduction in BCL-2 levels helped induce apoptosis in lung cancer cells

Lymphoma - Deoxycoformycin used to treat splenic marginal zone lymphoma

Malaria Vaccines - Recent findings illuminate research in malaria vaccines

Measles Vaccine - Efficient rescue of measles virus from cloned cDNA described

Melanoma - Paper reports late preclinical step validating novel melanoma vaccine

Melanoma Vaccine - Intracellular sorting signals do not affect melanoma vaccine efficacy

Melanoma Vaccine Development - T-cells elicited by Listeria expressing melanoma antigen characterized

Metapneumovirus Vaccine Development - Substitution in metapneumovirus protein determines growth in Vero cells

Myeloma - 2-Methoxyestradiol at low dose induced differentiation of myeloma cells

Myeloma - Zoledronic acid down-regulated adhesion molecules of bone marrow stromal cells

Neosporosis Vaccine Development - Microneme antigen NcMIC1 protects against cerebral neosporosis

Obstetrics - Hepatitis B antibodies in infants and toddlers may be maternal markers

Ovarian Cancer - Researchers' work adds to ovarian cancer body of knowledge

Ovarian Cancer - Topotecan in pretreated patients with recurrent ovarian carcinoma evaluated

Pandemic Influenza - Positive preclinical results reported on vaccine for pandemic influenza

Parkinson Disease - AAV2-mediated gene delivery to monkey putamen evaluated

Pertussis Vaccine Development - Pertussis virulence factor retains properties after production

Pertussis Vaccine Development - Vaccine prevents exacerbation of asthma due to Bordetella pertussis

Pneumococcal Vaccine Development - Universal pneumococcal vaccination of Italian infants is cost effective

Polio - Indonesia launches country's largest-ever immunization campaign

Polio Vaccine - Oral poliovirus strains do not persist after vaccine switch

Respiratory Medicine - Modeling control strategies of respiratory pathogens presented

Respiratory Syncytial Virus - New protein involved in infection of RSV on SPC-A1 cells identified

Retroviral Vectors - Mutations alter cytopathic effects in chimeric avian retroviral vectors

SARS Vaccine Development - SARS-CoV spike protein elicits specific humoral immune responses

SARS Vaccines - Research in SARS vaccines provides new insights

Sexual & Reproductive Health - Predictors of STD vaccine acceptability investigated

Shingles - A "pox" on shingles: vaccine proven effective

Smallpox Vaccine Development - Monitoring health care workers after smallpox vaccination described

Smallpox Vaccine Development - Vaccine shows activity in mouse model of vaccinia virus infection

Smallpox Vaccine Development - Vaccinia virion membrane protein required for cell entry and fusion

Smallpox Vaccine Development - Vaccinia virus tropism determined by unique virus receptor expression

Snake Venom - Antibodies discriminate native weak toxins from denaturated forms

Staphylococcal Vaccine Development - Antibody repertoires against Staphylococcus aureus compared

Streptococcus - Research offers GBS vaccine hope for newborn babies

Tuberculosis Vaccine Development - Ag85b and MPT64 DNA vaccines in model of tuberculosis examined

Tuberculosis Vaccines - Findings in tuberculosis vaccines provide new insights

Typhoid Fever - Vaccine for typhoid and food poisoning possible

Vaccine Adjuvant - Neem leaf extract acts as adjuvant for B16 melanoma surface antigen

Vaccine Delivery -  E. coli fimbriae function as mucosal carrier for antigen

Vaccine Delivery - Biphasic lipid vesicles used as delivery systems for protein antigen

Vaccine Delivery - Poly(L-lactic acid) nanoparticles used as gene delivery carriers

Vaccine Development - Continuous thermal procedure for preparation of plasmid DNA developed

Vaccine Development - EPIMHC is database of MHC-binding peptides for vaccinology

Vaccine Development - IFN-gamma in protein-free media is protected by protease inhibitors

Vaccine Development - Sendai virus nucleocapsid-like particles generated in yeast

Vaccine Efficacy - Prior exposure to carrier regulates responses to conjugate vaccine

Vaccine Vector - Engineered chromosomes not yet viable gene-delivery platforms

Vaccine Vector - PEGylated adenovirus vectors possess antibody evasion ability

Vaccine Vector - Transcription of self-inactivating lentiviral vectors examined

Vaccine Vector - Transduction of dermal tissue for autologous delivery of proteins reported

Vaccine Vector - Viral vectors to treat neurodegenerative disorders reviewed

Vaccine Vector Development - Influenza A virus vector expressing human IL-2 engineered

Vaccine Vectors - Vectors from rare adenovirus serotypes may be useful for vaccines

Vaccine Vectors - Vesicular stomatitis virus L cell line for VSV packaging developed

Vaccines Adjuvant - Findings advance knowledge in vaccines adjuvant research

Vaccines Vector - Researchers' data advance vaccines vector research

Varicella-Zoster Virus - Studies describe new findings in varicella-zoster virus research

Vector Development - New findings in vector development described

Yellow Fever Vaccine Development - Yellow fever viruses expressing foreign epitopes are vaccine candidates

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