Vector Development
Peptide for protein and vector neuronal targeting identified
Published in Vaccine Weekly, September 28th, 2005
According to recent research published in the journal Neurobiology of Disease, "A novel peptide with the binding characteristics of tetanus toxin was identified with phage display, for application in therapeutic protein and vector motor and sensory neuron targeting. A 12-mer phage library was biopanned on trisialoganglioside (GT1b ) and eluted with the tetanus toxin C fragment (rTTC). Phage ELISAs revealed increases in GT1b binding for the Tet1 and Tet2 phage clones when compared to peptideless phage (PLP)."
"rTTC displaced both...
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Source: Vaccine Weekly (2005-09-28)
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