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Ebola Vaccine Development

Humoral and CD8+ responses needed to protect against Ebola infection

Published in Vaccine Weekly, September 28th, 2005

Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection.

"Ebola virus (EBOV)-like particles (eVLP), composed of the EBOV glycoprotein and matrix viral protein (VP)40 with a lipid membrane, are a highly efficacious method of immunization against EBOV infection. The exact requirements for immunity against EBOV infection are poorly defined at this time. The goal of this work was to determine the requirements for EBOV immunity following eVLP vaccination," investigators in the United States report.

"Vaccination of BALB/c or C57BL/6 mice with eVLPs in conjunction with QS-21 adjuvant resulted in mixed...

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