Published in Vaccine Weekly, September 28th, 2005
Study 1: Co-immunization with DNA- and protein-based vaccines induced active immune suppression.
"Although immunization has been used for eliciting immune response, here we show that it can also induce immune suppression. When a DNA vaccine encoding a viral antigen such as the VP1 protein from the foot-and-mouth disease virus is administered together with its recombinant protein antigen or a viral preparation containing the same antigen, the immunized animals developed significantly reduced antigen-specific T cell-mediated responses and became impaired to subsequent...
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