Oral Vaccine

Cell surface display system for Lactococcus lactis described

Published in Vaccine Weekly, September 28th, 2005

Researchers describe a cell surface display system for Lactococcus lactis for the development of oral vaccines in a recent issue of Applied Microbiology and Biotechnology.

According to a study from Malaysia, "The food-grade Lactococcus lactis is a potential vector to be used as a live vehicle for the delivery of heterologous proteins for vaccine and pharmaceutical purposes. We constructed a plasmid vector pSVac that harbors a 255-bp single-repeat sequence of the cell wall-binding protein region of the AcmA protein. The recombinant plasmid was transformed into Escherichia coli and expression of the gene fragment was driven by the T7 promoter...

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Source: Vaccine Weekly (2005-09-28)

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