Cancer Vaccine Development
Cell lines from tumors induced by TC-1 cells characterized
Published in Vaccine Weekly, October 5th, 2005
"Escape of tumor cells from the host immune system is probably the most difficult obstacle to overcome in attempts to enhance the efficacy of immunotherapy of tumors. To solve the problem, animal models with escape mechanisms found in human tumors are needed. We have already established cell lines with substantially reduced expression of MHC class I molecules that were derived from oncogenic TC-1 cells producing E6 and E7 oncoproteins of HPV16," researchers in the Czech Republic...
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Source: Vaccine Weekly (2005-10-05)
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