DNA Vaccine Development
Reporter gene expression in dendritic cells investigated
Published in Vaccine Weekly, October 5th, 2005
"Dendritic cells (DC) play an integral role in plasmid DNA vaccination. However, the interaction between plasmid DNA and DC in vivo is incompletely understood. In this report, we utilize the sheep pseudo-afferent cannulation model to examine the interaction between plasmid DNA encoding enhanced green fluorescent protein (pEGFP) and afferent lymph DC (ALDC) following gene gun administration," scientists in Scotland report.
"The results show that peaks of fluorescent ALDC tended to appear around days 1-4 and 9-13, then erratically...
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Source: Vaccine Weekly (2005-10-05)
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