Influenza Vaccine Development
Neuraminidase-expressing DNAs protect against influenza virus infection
Published in Vaccine Weekly, October 5th, 2005
"The ability of a single dose of plasmid DNA encoding neuraminidase (NA) or hemagglutinin (HA) from influenza virus A/PR/8/34 (PR8) (H1N1) to protect against homologous virus infection was examined in BALB/c mice. In the present study, mice were immunized once with 30 mcg of NA or HA DNA by electroporation. Four weeks or 28 weeks after immunization, mice were challenged with a lethal dose of homologous virus and the ability of NA or HA DNA to protect the mice from influenza was evaluated," scientists in China report.
"We found that a single...
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Source: Vaccine Weekly (2005-10-05)
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