Vaccine Development
Killed but active microbes proposed for new vaccine paradigm
Published in Vaccine Weekly, October 12th, 2005
According to recent research from the United States, "We developed a new class of vaccines, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed vaccines. We removed genes required for nucleotide excision repair (uvrAB), rendering microbial-based vaccines exquisitely sensitive to photochemical inactivation with psoralen and long-wavelength ultraviolet light."
"Colony formation of the nucleotide excision repair mutants was...
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Source: Vaccine Weekly (2005-10-12)
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