Tuberculosis Vaccine

Neutrophils shuttle live bacilli to lymph nodes after BCG vaccination

Published in Vaccine Weekly, October 26th, 2005

Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.

According to recent research published in the journal Blood, "The early innate response after Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccination is poorly characterized but probably decisive for subsequent protective immunity against tuberculosis. Therefore, we vaccinated mice with fluorescent BCG strains in the ear dorsum, as a surrogate of intradermal vaccination in humans. During the first 3 days, we tracked BCG host cells migrating out of the dermis to the auricular draining lymph nodes...

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Source: Vaccine Weekly (2005-10-26)

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