Cancer Vaccine
CD4+ regulatory NKT cells suppress expansion of tumor antigen-specific CTLs
Published in Vaccine Weekly, October 26th, 2005
"NKT cells can produce large amounts of both Th1-and Th2-type cytokines and are an important regulatory cell type. To elucidate their role in acquired immunity, we examined the effect of human V alpha 24+V beta 11+ NKT cells or CD1d-specific ligand alpha-galactosylceramide (alpha GalCer) on the in vitro generation of antigen-specific CTLs from PBMCs using autologous MART-1(26-35) peptide-pulsed dendritic cells as stimulators. Flow cytometry using tetramer for MART-1(26-35) peptide revealed that NKT cells have inhibitory effects on CTL generation," scientists in the United...
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Source: Vaccine Weekly (2005-10-26)
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