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Epilepsy Vaccine Development

Autoantibodies may affect severity of epileptic seizures

Published in Vaccine Weekly, October 26th, 2005

Researchers have studied the efficacy of autoantibodies against glutamate/AMPA receptor subtype 3 and their ability to affect seizures.

According to recent research from Israel, "Do autoantibodies against glutamate/AMPA receptor subtype 3 affect the severity of seizures' Rats immunized with the GluR3B-peptide [amino acids (aa) 372-395] or with the control GluR3A-peptide (aa 245-274) produced the respective anti-GluR3B and anti-GluR3A antibodies (both types of autoantibodies found in some epilepsy patients). The GluR3B-immunized rats exhibited neuronal death and reactive gliosis in the brain, but not overt spontaneous seizures."

Yonatan Ganor and his...

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