Anthrax Vaccine Development

Monoclonal antibody protects against anthrax toxin

Published in Vaccine Weekly, November 16th, 2005

An anthrax lethal factor-neutralizing monoclonal antibody protects rats before and after challenge with anthrax toxin.

"Lethal factor (LF) is a component of anthrax lethal toxin (LeTx). We generated anti-LF murine monoclonal antibodies (MAbs) that show LeTx-neutralizing activity in vitro and in vivo. Anti-LF MAbs were generated by immunization with recombinant LF, and the MAbs showing LeTx-neutralizing activity in vitro were selected. Two MAbs with the highest affinities, 5B13B1 (dissociation constant [K_{d] ] ], 2.62 nM) and 3C16C3 (K_d , 8.18 nM), were shown to recognize the same or closely overlapping epitopes on domain III of LF," scientists writing in...}

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Source: Vaccine Weekly (2005-11-16)

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