HIV/AIDS Vaccine Development

HIV trials feasible with fewer animals if subjects repeatedly challenged with low doses

Published in Vaccine Weekly, November 16th, 2005

HIV vaccines and drug trials are feasible with fewer animals if subjects are repeatedly challenged with low doses.

According to a study from the United States, "Trials in macaque models play an essential role in the evaluation of biomedical interventions that aim to prevent HIV infection, such as vaccines, microbicides, and systemic chemoprophylaxis. These trials are usually conducted with very high virus challenge doses that result in infection with certainty.

"However, these high challenge doses do not realistically reflect the low probability of HIV transmission in humans, and thus may rule out preventive interventions that could protect against...

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Source: Vaccine Weekly (2005-11-16)

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