Drug Development
Newly synthesized 1,2,4-triazol-3-one derivatives showed antitumor activity
Published in Vaccine Weekly, November 30th, 2005
"New 2-phenacyl-1,2,4-triazol-3-ones were obtained by the reaction of 5-alkyl-1,2,4-triazol-3-ones with alpha-bromoacetophenone in an alkaline medium. Selective reduction of the side chain carbonyl group to hydroxy group was achieved with NaBH4," scientists in Turkey reported.
"The reaction of some compounds containing a phenolic hydroxyl with 4-toluenesulfonyl chloride or benzyl bromide in the presence of NaOH led to tosylated or benzylated derivatives. The tosylation or benzylation at the alcoholic hydroxyl was carried out in the presence of sodium metal,"...
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Source: Vaccine Weekly (2005-11-30)
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