West Nile Virus Vaccine
Structural basis of West Nile virus neutralization by antibody elucidated
Published in Vaccine Weekly, November 30th, 2005
"West Nile virus is a mosquito-borne flavivirus closely related to the human epidemic-causing dengue, yellow fever, and Japanese encephalitis viruses. In establishing infection these icosahedral viruses undergo endosomal membrane fusion catalyzed by envelope glycoprotein rearrangement of the putative receptor-binding domain III (DIII) and exposure of the hydrophobic fusion loop."
"Humoral immunity has an essential protective function early in the course of West Nile virus infection. Here, we investigate the mechanism of neutralization by...
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Source: Vaccine Weekly (2005-11-30)
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