Infectious Diseases

Streptococcus agalactiae pan-genome is vast

Published in Vaccine Weekly, November 30th, 2005

According to a study from Italy, the Streptococcus agalactiae pan-genome is vast.

"The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single genome does not reflect how genetic variability drives pathogenesis within a bacterial species and also limits genomewide screens for vaccine candidates or for antimicrobial targets."

"We have generated the genomic sequence of six strains representing the five major disease-causing serotypes of S. agalactiae, the main cause of neonatal infection in humans,"...

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Source: Vaccine Weekly (2005-11-30)

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