Liver Cancer

New alpha-fetoprotein-derived epitope in liver cancer identified

Published in Vaccine Weekly, November 30th, 2005

Researchers have identified a new alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients.

According to a study from England, "Alpha-fetoprotein (AFP) is a tumor-associated antigen in hepatocellular carcinoma and is a target for the development of a cancer vaccine. Four immunodominant AFP-derived HLA-A*0201-restricted peptides have been identified and the administration of these peptides with an adjuvant has stimulated AFP-specific CTL responses in hepatocellular carcinoma patients. However, no AFP-derived CD4 T-cell epitope has yet been reported and the status of AFP-specific CD4+ T-cell responses in hepatocellular carcinoma patients is not fully...

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Source: Vaccine Weekly (2005-11-30)

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