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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . December 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Addiction Medicine - Immunotherapy for treatment of drug abuse is reviewed

Adenovirus Vaccine - Adenovirus serotypes 4 and 7 vaccine strains were sequenced and compared

Gastroenteritis Vaccine - Shiga toxin subunit::rotavirus fusion protein protects against gastroenteritis

Yellow Fever Vaccine - New developments in flavivirus vaccines are reviewed

Adenovirus Vectors - Infectious mutants accumulate in stocks during propagation of adenoviruses

Adenovirus Vectors - Peptide-presenting libraries allow choice of peptide ligands for viral vector retargeting

Adverse Drug Effects - Relative disparities should be measured in terms of adverse events

Alzheimer Disease - New research in the area of Alzheimer disease detailed

Alzheimer Disease Vaccine - MPL with trehalose dicorynomycolate is effective vaccine adjuvant

Anthrax Vaccines Development - New data illuminates research in anthrax vaccines development

Apoptosis -  Gleditsia sinensis fruit extract induced apoptosis in human carcinoma cells

Apoptosis - Nano neodymium oxide induced cell death in non-small cell lung cancer cells

Aspergillosis - IFN-gamma overexpression promotes Aspergillus clearance in pulmonary aspergillosis

Atherosclerosis - Researchers' data advance atherosclerosis research

Avian Influenza - Pennsylvania governor announces plan to protect residents from avian influenza

Avian Influenza - Viral inactivation method being explored for development of bird flu vaccine

Bladder Cancer Vaccine - Moureau-Rio de Janeiro BCG strain reduces recurrence rate in bladder cancer

Breast Cancer Vaccine - Overexpression of protein fragment sensitizes MDA-MB-231 breast tumor cells to radiation

Bunyamwera Virus - Role of Bunyamwera virus glycoproteins in virus infectivity is examined

Cancer Drugs - Efficacy of doxorubicin improved via an enhanced intracellular delivery system

Cancer Therapy - Administration of propolis and its polyphenolic compounds delayed tumor formation and growth

Cancer Therapy - Continuous exposure to low-dose cisplatin induced apoptosis in rat hepatoma AH-109A cells

Cancer Therapy - Findings describe new data in cancer therapy research

Cancer Therapy - Mastoparan could be administered via a tumor selective delivery system

Cancer Therapy - Novel aminosubstituted xanthenones overcame multidrug resistance toward MES-SA/Dx5 cells

Cancer Therapy - PS-341 did not improve condition in patients with metastatic pancreatic adenocarcinoma

Cancer Vaccine - Electrical charge promotes viability and physiology of dendritic cells

Cancer Vaccine - Epitope from cancer testis antigen was presented by dendritic cells to CD4+ T cells

Cancer Vaccine - Mechanism of DNA topoisomerase poisoning was investigated

Cervical Cancer Vaccine - High prevalence of HPV-16 found was in squamous intraepithelial lesions in Portuguese women

Cervical Cancer Vaccine - Vaccine against human papillomavirus in adolescents reaches market in 2006

Chemotherapy - Imatinib and hydroxyurea used to treat progressive glioblastoma multiforme

Chemotherapy - Weekly paclitaxel used to treat patients with advanced melanoma

Cholera Epidemiology - Children bear the brunt of cholera in the slums of Kolkata, India

Clinical Trials - Companies complete feasibility study for production of recombinant botulinum vaccine

Clinical Trials - Irish pharmaceutical company reports launch of reverse transcriptase phase III trials

Collaborations - German companies collaborate on monoclonal antibodies to human GPCR cancer targets

Complementary & Alternative Medicine - Diterpenoids from the Chinese herb Rabdosia rubescens affected NF-kappa B in breast cancer

Complementary & Alternative Medicine - Glycolipids fraction from spinach displayed anticancer activity

Complementary & Alternative Medicine - Pomegranate fruit juice proposed for chemoprevention and chemotherapy of prostate cancer

DNA Vaccine - Oligodeoxynucleotide enhances efficacy of DNA vaccine and treats autoimmune disease

Dendritic Cell Vaccine - Melanoma cell necrosis facilitates transfer of antigens onto dendritic cells

Dendritic Cell Vaccine - Natural killer dendritic cell cross-talk is effective for cancer immunotherapy

Dengue Virus - Humanized NOD/SCID mice were developed to study dengue virus and test antidengue products

Drug Delivery - Pros, cons of needle-free immunization, other delivery methods are reviewed

Drug Development - Agreement signed to develop process, manufacture AIDS vaccine candidate for trials

Drug Development - All volunteers in phase I trial for plague vaccine are successfully vaccinated

Drug Development - Pharma company to license novel drug target for HIV treatment

Drug Development - Preliminary results from ragweed allergy trial expected in early 2006

Drug Safety - Methods for clearing viruses and TSE agents from biologicals are under development

Finance - Dip in Manapol sales contributes to company's third-quarter net loss of $1.6M

Foot-&-Mouth Disease Vaccine - New mucosal vaccine against foot-and-mouth disease virus protects mice and swine

Gastroenterology - Lamina propria dendritic cells play large role in gastrointestinal physiology

HIV/AIDS Diagnostics - Results demonstrate importance of reagent selection for monitoring of HIV responses

HIV/AIDS Prevention - Phase II trial initiated in South Africa to test HIV vaccine candidate

HIV/AIDS Research - Behavioral study shows patients willing to consider self-injectable therapy

HIV/AIDS Research - Clinical trial shows MK-0518 tablet has potent reduction in viral load as monotherapy

HIV/AIDS Research - HIV/AIDS research shows new drugs offer alternatives for individualized care

HIV/AIDS Research - Kaletra combination therapy shown to maintain undetectable viral load in HIV patients

HIV/AIDS Research - New European HIV treatment guidelines recommend boosted Invirase as first choice protease inhibitor

HIV/AIDS Vaccine Development - Envelope vaccines derived from South African subtype C HIV-1 TV1 strain have been evaluated

HIV/AIDS Vaccine Development - Semliki Forest virus particles efficiently expand HIV-1-specific T cell responses

Infectious Bronchitis Virus - Trafficking signals in bronchitis virus spike protein are needed for virus infection

Influenza - U.S. FDA advisory committee affirms safety of Tamiflu in children

Influenza Vaccine - Children with solid tumors should receive yearly influenza immunizations

Influenza Vaccine - Conserved influenza A epitopes in humans and transgenic mice are described

Influenza Vaccine - Knowledge, attitude, and behavior affect influenza immunization of medical residents

Influenza Vaccine - Macro-epidemiology of influenza vaccination in 56 countries is presented

Influenza Vaccine - Respiratory mucosal immunity from antiviral vaccination is disappointing

Influenza Vaccines - Findings in influenza vaccines provide new insights

Legal Issues - Drug makers end Tamiflu dispute

Leukodystrophy - Data advance knowledge in leukodystrophy research

Malaria Vaccines - New findings in the area of malaria vaccines described

Medicaid - Texas Medicaid begins covering HIV resistance testing

Medical Policy - Policies can increase influenza and pneumococcal immunizations

Meningitis Pathogenesis - Salivary IgA plays role in host defense to Neisseria meningitidis

Mucosal Immunization - Secretory IgA from colostrum and milk is used for oral passive immunization

Pancreatic Cancer Therapy - Dehydroxymethylepoxyquinomicin and tumor necrosis factor-alpha used to treat pancreatic cancer

Pancreatic Cancer Therapy - Lupeol induced apoptotic death of human pancreatic adenocarcinoma cells

Pediatric Vaccine - Compliance and resistance to child immunization among Swiss mothers is examined

Pediatric Vaccine - Understanding verbal pain expression in children can reduce immunization pain

Personnel - Keith Gregg and Paul Hopper join board of antibody-based treatment developer

Pertussis Vaccine - Antibodies directed against pentasaccharide-tetanus toxoid conjugate exhibit anti-endotoxin activity

Pertussis Vaccine - Nucleic acid amplification tests for diagnosis of Bordetella infections are reviewed

Pertussis Vaccines - Researchers' findings advance pertussis vaccines research

Pneumococcal Vaccine - ELISA is developed to detect invasive pneumococcal disease in children

Pneumococcal Vaccine - Microbes may modulate antibody response to glucuronoxylomannan in AIDS

Pneumococcal Vaccine - Past polysaccharide vaccine did not affect pneumococcal vaccine response in HIV-infected Ugandans

Protein Production -  Medicago truncatula is a promising protein production system

Proteomics - Pseudorabies virus UL17 protein is characterized

Rotavirus Vaccine - Antibody responses against rotavirus protein after vaccination or infection have been evaluated

Rotavirus Vaccine - Method for triple-layered rotavirus virus-like particle production is developed

Rotavirus Vaccine - Vaccination reduces disease burden and health costs of rotavirus diarrhea in Vietnam

Rubella Epidemiology - Measles and rubella vaccination efforts are needed among young women in Argentina

Rubella Risk Factors - Country of origin is risk factor for rubella infection during pregnancy

Rubella Vaccine - Seroprevalence of rubella antibodies among antenatal patients in South Africa is reported

Skin Cancer Vaccine - Melanoma progression occurs despite high levels of CD8+ T cells

Smallpox Vaccine - Combinations of antibodies to vaccinia virus proteins protect against respiratory challenge

Smallpox Vaccine - Maxi-Vac software aids in planning mass smallpox vaccination clinics

Tuberculosis - New TB vaccine enters phase I clinical trial

Tuberculosis Vaccine - Recombinant antigens of M. tuberculosis for serodiagnosis were purified

Tuberculous Meningitis - BCG vaccination improves outcome of tuberculous meningitis in children

Typhoid Fever - Enteric fever in travelers is reviewed

Typhoid Vaccines - Clinical study of single-dose oral typhoid vaccine begins in Vietnam

Vaccine Delivery - Histidylated lipid-modified Sendai viral envelopes enhance membrane fusion

Vaccine Delivery - Packaging method of oligodeoxynucleotides using nanoparticles is developed

Vaccine Efficacy - Diphtheria with polyneuropathy is found in closed community despite booster vaccination

Vaccine Efficacy - Newcastle disease virus expressing foreign viral antigen is highly immunogenic in primates

Vaccine Efficacy - Response to antigen contributes more to immunological memory than cell number increases

Vaccine Registries - Electronic billing systems need improvement to maintain accurate vaccine registries

Vaccine Research - New gene chip could ehance scientists' ability to develop vaccines

Vaccine Safety - Persistent pruritic nodules and contact allergy to aluminum were reported after vaccinations

Vaccine Safety - Reports to vaccine adverse event reporting system are used to track vaccine lots

Vector Development - Hereditary persistence of fetal hemoglobin 2 enhancer increases onco-retrovirus vector expression

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