Published in Vaccine Weekly, December 21st, 2005
According to a study from the United States, "A fusion protein containing the shiga toxin-1 B subunit (STB) linked to a 90-amino-acid peptide (aa residues 86-175) from simian rotavirus (SA-11) nonstructural protein NSP4 was synthesized in Escherichia coli. Mice orally inoculated with 60 jig of STB::NSP4(90) fusion protein per dose generated higher humoral and intestinal antibody titers than mice inoculated with 30 mcg of NSP4 alone. Serum anti-NSP4 IgG2a isotype titers were substantially greater than IgG1 titers, suggesting a dominant Th1...
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