Pneumonia Vaccine
Age-related changes occur in light-chain gene usage in response to pneumococcal polysaccharides
Published in Vaccine Weekly, December 28th, 2005
According to recent research from the United States, "Streptococcus pneumoniae is a human bacterial pathogen responsible for serious infections including pneumonia. The currently licensed polysaccharide vaccine provides 60 to 80% protection in young adults, but in the elderly the vaccine efficacy is drastically reduced despite normal antibody levels."
"We hypothesized that the reduced vaccine efficacy in the elderly results from altered variable gene family usage. We have analyzed the light-chain gene usage in 20 young...
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Source: Vaccine Weekly (2005-12-28)
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