HIV/AIDS Pathogenesis
Cytotoxic T lymphocytes can kill 0.7 to 3 HIV-infected target cells per day
Published in Vaccine Weekly, December 28th, 2005
"The antiviral role of CD8+ cytotoxic T lymphocytes (CTLs) in human immunodeficiency virus type 1 (HIV-1) infection is poorly understood. Specifically, the degree to which CTLs reduce viral replication by killing HIV-1-infected cells in vivo is not known," scientists in the United States report.
"Here we employ mathematical models of the infection process and CTL action to estimate the rate that CTLs can kill HIV-1-infected cells from in vitro and in vivo data," wrote W.D. Wick and colleagues at the Fred Hutchinson Cancer Research Center in Seattle.
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Source: Vaccine Weekly (2005-12-28)
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