Published in Vaccine Weekly, December 28th, 2005
"APL is a form of acute myeloid leukemia (AML) caused by a specific chromosomal translocation: t(15;17). This translocation creates a fusion between the promyelocytic (PML) leukemia gene and the retinoic acid receptor alpha (RAR alpha) gene to arrest the maturation of myeloid cells at the promyelocytic stage, leading to increased proliferation of promyelocytes," scientists reported in the journal Drugs of the Future.
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