Vaccine Weekly

Cervical Cancer - Pharma company submits biologics license application for papillomavirus vaccine to U.S. FDA

Chickenpox Vaccine - Varicella vaccination in Australia is the focus of review

Escherichia Coli Vaccine - Live diarrheal vaccine imprints Th2 cell bias and is anti-inflammatory

SARS Vaccine - Inactivated virus immunization modulates immune response to SARS spike glycoprotein

Adenovirus Vector - Oncolytic adenovirus replicates selectively in tumors

Allergy & Immunology - Mycobacteria exposure primes immune system for evolutionarily diverse heat shock proteins

Antigen Receptors - Norovirus capsid protein forms particle that binds to histo-blood group antigen receptors

Apoptosis - MDM2 antagonists induced apoptosis in acute myeloid leukemia

Apoptosis - New marine natural compounds exhibited cyclin-dependent kinase inhibitor activity

Avian Influenza - Australian government's preparation for a bird flu outbreak is welcome

Avian Influenza - Chinese, American medical centers sign affiliation agreement for avian flu virus

Avian Influenza - Risk management services provider advises companies to prepare for avian flu pandemic

Avian Influenza - Testing agreement signed with U.S. NIH for drug against Avian influenza virus H5N1

Bacillus Anthracis - Anthrax toxin enhances VCAM-1 expression in endothelial cells

Bioterrorism - Expert panel evaluates implementation of Project BioShield and procurement of biodefense vaccines

Breast Cancer - Progesterone used to inhibit human breast cancer cell growth

Brucellosis Vaccine - Report describes selection of protective epitopes for Brucella melitensis by DNA vaccination

Cancer Therapy - Association between cardiac toxicity and antineoplastic agents discussed

Cancer Vaccine - CCK₁ cholecystokinin receptors are abundant in gastric mucosa

Cancer Vaccine - Chelator lipid promotes stable binding of His-tagged proteins to liposomes

Cancer Vaccine - Cooperation between CD4 T cells protects against tumors in MUC.1 mice

Cancer Vaccine - Vaccination and adoptive T cell transfer restore immunity in lymphopenic cancer patients

Chickenpox Vaccine - Rate of varicella vaccine rash is not increased in children with eczema

Chlamydia Trachomatis Therapy - Early chlamydia treatment interferes with immunity effect on population susceptibility

Clinical Trials - Company updates clinical trial programs for therapeutic cancer vaccines

Clinical Trials - Phase I clinical study of vaccine in advanced renal cell cancer initiated

Clinical Trials - Trial results show benefits of infliximab in patients with ulcerative colitis

Colorectal Cancer Vaccine - DNA vaccine causes rejection of colorectal cancer and melanoma tumors

Complementary & Alternative Medicine - New alkaloid derived from roots of Aconitum karacolicum Rapcs demonstrated antiproliferative activities

Contraceptive Vaccine - Sperm-associated antigen exhibits contraceptive potential

Diabetes Therapy - Fowlpox virus was used for in vitro gene delivery to pancreatic islets

Drug Delivery - Report reviews the use of mucoadhesive polymers in vaginal delivery

Drug Delivery - U.S. FDA approves Hylenex

Drug Development - F-18-fluorobenzoate idarubicin derivative synthesized

Endometrial Cancer - Docetaxel used to treat advanced or metastatic endometrial cancer

Feline Immunodeficiency Virus - Feline immunodeficiency virus gp36 ectodomain has been characterized

Gene Research - Companies announce strategic alliance related to lentiviral vector manufacturing

HIV/AIDS Research - U.S. NIAID awards $22.75 million contract to expand AAV-based HIV vaccine program

HIV/AIDS Research - U.S. NIH awards $32 million contract for ongoing HIV vaccine research

HIV/AIDS Transmission - HIV-1-specific CD8+ T cell responses are factors in viral evolution in mothers/infants

HIV/AIDS Vaccine - Costimulation with CD80 and CD137L enhances HIV-specific CD8 T cell responses

HIV/AIDS Vaccine - Negative binomial regression was used to confirm IL-12 adjuvant activity

HIV/AIDS Vaccine - Probes can help development of Fab-based anti-HIV-1 therapeutics

Hepatitis A Vaccine - Vaccinating toddlers against hepatitis A in one Israeli community reduced overall incidence

Hepatitis B Vaccine - Hepatitis B vaccine non-responsiveness analyzed among health care workers from an endemic area

Hepatitis B Virus - Changes of the major hydrophilic loop of the hepatitis B antigen are not rare

Hepatitis Vaccine - Virus coinfection model reveals reciprocal immunomodulation

Human Papillomavirus Vaccine - Papillomavirus E6 and E7 long peptides control virus-induced lesions

Huntington Disease - Small interfering RNAs show promise as treatment for Huntington disease

Influenza - Chiron Vaccines partners with Kiwanis to encourage widespread influenza education, vaccination

Influenza - Independent research laboratory to evaluate proprietary technology for boosting influenza vaccine

Influenza Vaccine - Biopharmaceutical supply channel innovator receives U.S. distribution deal