Published in Vaccine Weekly, January 4th, 2006
"HIV-specific CD8 T cell responses are defective in chronic HIV infection. In this study, we report that costimulation with either CD137L (4-1BBL) or CD80 (B7.1) enhanced the antigen-specific expansion and acquisition of effector function by HIV-specific memory CD8 T cells," scientists writing in the Journal of Immunology report.
"Antigen-specific T cells from recently infected donors showed maximal expansion with single costimulatory molecules. Dual costimulation of T cells from recently infected donors or from healthy donors responding to influenza epitopes...
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