SARS Vaccine

Inactivated virus immunization modulates immune response to SARS spike glycoprotein

Published in Vaccine Weekly, January 4th, 2006

Gene-based and inactivated virus immunization modulates the immune response to the severe acute respiratory syndrome spike glycoprotein.

"Although the initial isolates of the severe acute respiratory syndrome (SARS) coronavirus (CoV) are sensitive to neutralization by antibodies through their spike (S) glycoprotein, variants of S have since been identified that are resistant to such inhibition. Optimal vaccine strategies would therefore make use of additional determinants of immune recognition, either through cellular or expanded, cross-reactive humoral immunity," scientists writing in the Journal of Virology report.

"[In our report], the...

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Source: Vaccine Weekly (2006-01-04)

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