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Measles Vaccine

Long untranslated regions of measles virus M and F genes control virus replication

Published in Vaccine Weekly, January 4th, 2006

Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity.

According to a study from Japan, "Measles is still a major cause of mortality mainly in developing countries. The causative agent, measles virus (MeV), is an enveloped virus having a nonsegmented negative-sense RNA genome, and belongs to the genus Morbillivirus of the family Paramyxoviridae. One feature of the moribillivirus genomes is that the M and F genes have long untranslated regions (UTRs)."

"The M and F mRNAs of MeV have 426-nucleotide-long 3' and 583-nucleotide-long 5' UTRs, respectively. Though these long UTRs occupy as much as...

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