Published in Vaccine Weekly, January 4th, 2006
"Rat experimental autoimmune myocarditis (EAM) is a T cell-mediated disease that resembled the giant cell myocarditis seen in humans. Soluble CTLA4 improves some autoimmune diseases by blocking co-stimulatory signals on T cells. We investigated the effect of hydrodynamics-based naked plasmid DNA-encoding CTLA4-immunoglobulin (Ig) gene delivery," researchers in Japan report.
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