Myocarditis Vaccine
Naked plasmid DNA-encoding CTLA4-Ig gene prevents autoimmune myocarditis
Published in Vaccine Weekly, January 4th, 2006
"Rat experimental autoimmune myocarditis (EAM) is a T cell-mediated disease that resembled the giant cell myocarditis seen in humans. Soluble CTLA4 improves some autoimmune diseases by blocking co-stimulatory signals on T cells. We investigated the effect of hydrodynamics-based naked plasmid DNA-encoding CTLA4-immunoglobulin (Ig) gene delivery," researchers in Japan report.
"Lewis rats were immunized with cardiac myosin and treated with hydrodynamic-based transfection, namely a rapid tail vein injection of a large volume of pCAGGS...
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Source: Vaccine Weekly (2006-01-04)
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