Vaccine Vector
Lentiviral vector in Pluronic F127 gel facilitates delivery to CNS
Published in Vaccine Weekly, January 4th, 2006
"Lentiviral vectors have been demonstrated as efficient tools for gene delivery to the CNS. We describe a novel approach for vector delivery using the thermoresponsive gel Pluronic F127 as a carrier," researchers in England report.
"An HIV-1 lentiviral vector expressing GFP was contained in various concentrations of gel (15, 30, and 40%) and applied to cultures of 293T cells. FACS analysis of cells transduced with 8 ng of lentiviral vector revealed a similar transduction efficiency for each gel concentration compared to vector added to cells...
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Source: Vaccine Weekly (2006-01-04)
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