Published in Vaccine Weekly, January 4th, 2006
"Lentiviral vectors have been demonstrated as efficient tools for gene delivery to the CNS. We describe a novel approach for vector delivery using the thermoresponsive gel Pluronic F127 as a carrier," researchers in England report.
"An HIV-1 lentiviral vector expressing GFP was contained in various concentrations of gel (15, 30, and 40%) and applied to cultures of 293T cells. FACS analysis of cells transduced with 8 ng of lentiviral vector revealed a similar transduction efficiency for each gel concentration compared to vector added to cells...
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