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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . January 11th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Atherosclerosis Vaccine - Vaccine may enable immunomodulation of atherosclerosis

Diabetes Vaccine - DNA vaccine ameliorates type 1 diabetes in NOD mice

Meningitis Vaccine - Meningococcal C conjugate vaccine is immunogenic in preterm infants

Rotavirus Vaccine - Introduction of rotavirus vaccines is expected to substantially reduce mortality

Sepsis Vaccine - Detoxified endotoxin vaccine protects against lethal polymicrobial sepsis

Adeno-Associated Viral Vector - Efficient gene expression is produced by trans-splicing adeno-associated viral vectors

Alzheimer Disease Therapy - Fragment of A-beta-specific monoclonal antibody reduces A-beta deposits in brain

Animal Models - Tissue-specific transgenic birds with lentiviral vectors have been generated

Antivenom Vaccine - Neutralizing antibody against scorpion venom is characterized

Apoptosis - Clonogenic tumor growth inhibited by Smac

Apoptosis - Ircinin-1 induced apoptosis in human melanoma cells

Cancer Vaccines - Reports add new data to Cancer Vaccines research

Apoptosis - Low- and high-molecular-weight poly(L-lysine)-DNA complexes initiate apoptosis differently

Bioterrorism - Biodefense program to develop vaccines and treatments for use in biowarfare applications

Breast Cancer - Reduced dose capecitabine deemed effective treatment in metastatic breast cancer

Breast Cancer - Study characterized antibodies involved in malignancy-induced autoimmunity to MUC1

Breast Cancer - Weekly administration of docetaxel and paclitaxel used to treat breast cancer

Breast Cancer Vaccine - Immunization with mucin 1 and its coding DNA had anti-tumor effect

Cancer Vaccines - Reports advance knowledge in Cancer Vaccines research

Cancer Therapy - Mechanism of an anticancer lysophospholipid described

Cancer Therapy - Nonsteroidal anti-inflammatory drugs marked for development into anticancer agents

Cancer Therapy - Studies add new findings to Cancer Therapy body of knowledge

Cancer Vaccine -  Psidium guajava extracts exert antitumor effect

Cancer Vaccine - Adenovirus-mediated transfer of FRNK augments drug-induced cytotoxicity

Cancer Vaccine - Herpes simplex virus type-1 amplicons linked to vaccine generation in lymphoblastic leukemia

HIV/AIDS Vaccines - New findings in HIV/AIDS Vaccines described

Cancer Vaccine - Knowledge of metastases and their microenvironments aids therapy design

Cancer Vaccine - Monoclonal antibodies for MK-1/Ep-CAM have been prepared

Cancer Vaccine - Neutralizing intrabodies against Etk kinase impair cellular transformation

Cancer Vaccine - Study identified amino acids of Sindbis virus protein involved in targeting tumor metastases

Cancer Vaccine - Tumor cell-pulsed dendritic cells and activated lymphocytes prolong survival

Cancer Vaccines - New data illuminates research in Cancer Vaccines

Chemotherapy - Researchers publish new studies and findings in the area of chemotherapy

Cholera Vaccines - Recent findings illuminate research in Cholera Vaccines

Collaborations - Roche files IND with U.S. FDA for antibody developed under collaboration

Colon Cancer Vaccine - Epitope-specific immunization inhibits epidermal growth factor receptor signaling

DNA Vaccines - Researchers describe findings in DNA Vaccines studies

Diabetes Vaccine - Glucagon-like peptide-1 plasmid is constructed for type 2 diabetes therapy

Drug Development - N-acylethanolamines and other antimitotic agents evaluated as possible inductors of apoptosis

Drug Development - Proteasome inhibitors evaluated in lymphoid malignancies

Drug Development - Synthesis and biological evaluation of polyhydroxycurcuminoids described

Finance - Cell therapy report added to Research & Markets' offerings

Glioblastoma - Response of glioblastomas to EGFR kinase inhibitors linked to molecular determinants

HIV/AIDS Seroconversion - HIV-1 variation determined within several weeks of estimated transmission

HIV/AIDS Vaccine - Adenoviruses encoding HIV Tat and SIV Gag enhanced cellular immunity to SIV Gag

HIV/AIDS Vaccine - Boost regimen induced HIV type 1-specific T cells

HIV/AIDS Vaccine - CD62L expression is not useful as marker for vaccine-elicited cytotoxic T lymphocytes

HIV/AIDS Vaccine - Gag-Env pseudovirion vaccine induced neutralizing antibodies against HIV

HIV/AIDS Vaccine - HIV-1 Gag dimerization-induced assembly involves multi-step pathway

HIV/AIDS Vaccines - Findings describe new data in HIV/AIDS Vaccines research

Hepatitis B Virus - Hepatitis B virus surface antigen characterized from a recombinant cell line

Hepatitis B Virus - New data illuminates research in Hepatitis B Virus

Hepatocellular Cancer - Hepatocellular carcinoma curbed by universal HBV vaccination

Herpes Simplex Virus - Neurokinin receptor signaling affects immune defense against genital herpes

Herpes Vaccine - Glycoprotein vaccine decreases herpes simplex virus shedding into genital tract

Human Papillomavirus Vaccine - Adjuvanted HPV vaccine fails to protect against anogenital warts

Human Papillomavirus Vaccine - CD8+ T cells from DNA vaccine control tumors through Fas-FasL pathway

Human Papillomavirus Vaccine - Report describes system for detecting HPV

Human Papillomavirus Vaccine - Study characterized HPV-16 E6 DNA vaccines employing intercellular spreading strategies

Infectious Disease - Rotavirus vaccine gets positive opinion from European regulatory authorities

Infectious Diseases - New fight against polio launched in Indonesia

Influenza - CAIV-T data show 55% reduction in influenza illness compared to injectable influenza vaccine

Influenza Vaccine - Interactive voice response reminders increase preventive service utilization

Influenza Vaccine - Intervention increases influenza vaccination rates among doctors but not nurses

Influenza Vaccine - Report outlines Society position on influenza vaccination for healthcare workers

Influenza Vaccine - Review examines incidence of influenza and associated illness in children

Influenza Vaccine - Tailored interventions increase influenza vaccination rates in inner city

Influenza Vaccines - Studies describe new findings in Influenza Vaccines research

Leukemia - Cladribine used to treat hairy cell leukemia

Liver Cancer - Recent findings in Liver Cancer provide new insights

Lung Cancer - Pemetrexed used to treat non-small cell lung cancer

Lung Cancer - Role of pemetrexed in treatment of small-cell lung cancer evaluated

Lymphoma Vaccine - Vaccination with idiotypic protein or DNA failed to prolong dormancy in BCL1 lymphoma

Malaria Research - Study of merozoite surfaces provides insight into erythrocyte invasion, anti-parasite immunity

Measles Vaccine - SLAM expression mediates measles virus infection in nonpermissive cells

Melanoma - Pegylated arginine deiminase used to treat patients with metastatic melanoma

Melanoma Vaccine - Dendritic cells pulsed with melanoma-associated antigen gp100-derived peptide elicit CD8+ immunity

Melanoma Vaccine - Fusion protein of IL-2 and diphtheria toxin does not eliminate regulatory T lymphocytes

Melanoma Vaccine - Marked differences found in melanoma antigen-specific T cell responsiveness

Meningitis Vaccine -  Haemophilus influenzae type b vaccinations are needed in Poland

Meningitis Vaccine - Meningococcal conjugate vaccine studies demonstrate immunogenicity and safety

Mergers & Acquisitions - Biotech company broadens diabetes pipeline with acquisition of Nurel Therapeutics

Mergers & Acquisitions - GlaxoSmithKline closes acquisition of vaccine developer

Metapneumovirus Vaccine - Viral proteins provide protection against virulent avian metapneumovirus

Microencapsulation - Micro- and nanospheres used for DNA encapsulation are characterized

Mucosal Immunization - Non-toxic enterotoxin-based chimeric protein induces immune memory

Multiple Myeloma Vaccine - SSX cancer testis antigens are expressed in most multiple myeloma patients

Neospora Vaccine - Native surface protein NcSRS2 reduces congenital Neospora caninum transmission

Neuroblastomas - ZD1839 inhibited neuroblastoma cell proliferation

Non-Hodgkin Lymphoma - Positive data reported from phase II clinical trial of FavId following Rituxan

Ovarian Cancer - HSV oncolytic therapy recruits immune effector cells in ovarian cancer

Pediatric Vaccine - Article addresses survey design in studies exploring barriers to pediatric immunizations

Pediatric Vaccine - Parental beliefs toward childhood vaccines identify barriers to vaccination

Pertussis Vaccine - Decrease in pertussis vaccination coverage is examined

Polio Vaccine - Vaccination schedules affect excretion of oral poliovirus vaccine strains

Prion Disease - B cell repertoire is severely selected against endogenous cellular prion protein

Prostate Cancer - Quercetin inhibited prostate cancer cell proliferation

Protein Production - Oxygen-limited batch process provides control for recombinant protein processes

Protozoa Drug Development - Protozoan parasite-specific carbohydrate structures may be used for drug development

Rheumatoid Arthritis Therapy - Adeno-associated virus type 5 enhances gene transfer to arthritic joints

Rotavirus Gastroenteritis - Data from 70,000-infant phase III trials support the efficacy and safety of Rotateq vaccine

Rotavirus Vaccine - VP7 gene of human rotaviruses isolated in Paraguay is characterized

Rotavirus Vaccines - New research in the area of Rotavirus Vaccines detailed

SARS Vaccine - Antibodies recognizing epitope on SARS coronavirus spike protein are characterized

Smallpox - U.S. FDA accepts investigational new drug application for smallpox drug, grants fast-track status

Streptococcus Epidemiology - Clonal association found between Streptococcus pneumoniae serotypes 23A and 23F

T Cells - T cell depletion enhances dendritic cell cytotoxic T lymphocyte response

Thyroid Cancer Vaccine - Autologous tumor cell lines have been developed for dendritic cell vaccination

Thyroid Cancer Vaccine - Vascular endothelial growth factor is potential thyroid tumor target

Tuberculosis Vaccine - Attitudes of French doctors toward BCG use vary widely

Vaccine Development - Dendritic cells for clinical application were generated under serum-free conditions

Vaccine Development - Downstream processing of viral vectors and vaccines is changing

Vaccine Efficacy - Hepatitis A immunization program aimed at child-care centers proves successful

Vaccine Vector - Akt/protein kinase B activation contributes to NF-kappa B-dependent CXCL10 expression

Vector Development - Review examines cellular factors influencing Semliki Forest Virus vector biology

Virus-Like Particles - Report describes deletion analysis of sapovirus VP1 gene for assembly of virus-like particles

Yellow Fever Vaccine - Live attenuated yellow fever protein allows for presentation of T cell epitopes

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