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Nicotine Vaccine

Nicotine conjugate vaccine elicits dose-related immunogenicity in tobacco smokers

Published in Vaccine Weekly, January 18th, 2006

A nicotine conjugate vaccine elicits dose-related immunogenicity in tobacco smokers.

"Immunotherapy is a novel potential treatment for nicotine addiction. The aim of [our] study was to assess the safety and immunogenicity of a nicotine conjugate vaccine, NicVAX, and its effects on smoking behavior," investigators in the United States report.

According to D.K. Hatsukami and colleagues at the University of Minnesota, "Smokers (N=68) were recruited for a noncessation treatment study and assigned to 1 of 3 doses of the nicotine vaccine (50, 100, or 200 mcg) or placebo. They were injected on days 0, 28, 56, and 182 and monitored for a period of 38...

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